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Phenytoin Amphetamines may delay intestinal imbibition of phenytoin; co-administration of phenytoin may produce a synergistic anticonvulsant Opération.
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Plasma concentrations of unconverted lisdexamfetamine are low and transient, generally becoming nenni-quantifiable by 8 hours after économie. The plasma elimination half-life of lisdexamfetamine typically averaged less than one hour in studies of lisdexamfetamine dimesylate in volunteers. Dextroamphetamine is known to inhibit monoamine oxidase. The ability of dextroamphetamine and its metabolites to inhibit various P450 isozymes and other enzymes has not been adequately elucidated. In vitro experiments with human microsomes indicate minor inhibition of CYP2D6 by amphetamine and minor inhibition of CYP1A2, 2D6, and 3A4 by Je or more metabolites, ravissant there are no in vivo studies of p450 enzyme inhibition.
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